Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate

The polymerization of the thiol-containing monomers further increases the ROS level inside the mitochondria, thereby autocatalyzing the polymerization process and creating fibrous polymeric structures.

Spatiotemporal Self-Assembly of Peptides Dictates Cancer-Selective Toxicity

Optimum balance between hydrophobicity and hydrophilicity is a critical factor for achieving self-assembly inside the mitochondria, thereby providing greater selectivity against cancer cells.

Mitochondria localization induced self-assembly of peptide amphiphiles

Mito-FF preferentially accumulates inside mitochondria and reaches the critical aggregation concentration to form a fibrous nanostructure. The Mito-FF fibrils induce mitochondrial dysfunction via membrane disruption to cause apoptosis.

Cloaking Nanoparticles with Protein Corona Shield.

Targeted drug delivery using nanoparticles can minimize the side effects of conventional pharmaceutical agents and enhance their efficacy. So we present a targeting strategy for nanoparticles incorporated with a supramolecularly pre-coated recombinant fusion protein.