Spatiotemporal Self-Assembly of Peptides Dictates Cancer-Selective Toxicity

Optimum balance between hydrophobicity and hydrophilicity is a critical factor for achieving self-assembly inside the mitochondria, thereby providing greater selectivity against cancer cells.

Self‐Assembly of Mitochondria‐Targeted Photosensitizer in Hypoxia

The mitochondria‐targeted photosensitizer localized to mitochondria and induced apoptosis of cancer cells both normoxic and hypoxic conditions through generation of ROS.

Mitochondria localization induced self-assembly of peptide amphiphiles

Mito-FF preferentially accumulates inside mitochondria and reaches the critical aggregation concentration to form a fibrous nanostructure. The Mito-FF fibrils induce mitochondrial dysfunction via membrane disruption to cause apoptosis.

Cloaking Nanoparticles with Protein Corona Shield.

Targeted drug delivery using nanoparticles can minimize the side effects of conventional pharmaceutical agents and enhance their efficacy. So we present a targeting strategy for nanoparticles incorporated with a supramolecularly pre-coated recombinant fusion protein.