• Image Slideshow

    Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate

    The polymerization of the thiol-containing monomers further increases the ROS level inside the mitochondria, thereby autocatalyzing the polymerization process and creating fibrous polymeric structures.
  • Image Slideshow

    Spatiotemporal Self-Assembly of Peptides Dictates Cancer-Selective Toxicity

    Optimum balance between hydrophobicity and hydrophilicity is a critical factor for achieving self-assembly inside the mitochondria, thereby providing greater selectivity against cancer cells.
  • Image Slideshow

    Mitochondria localization induced self-assembly of peptide amphiphiles

    Mito-FF preferentially accumulates inside mitochondria and reaches the critical aggregation concentration to form a fibrous nanostructure. The Mito-FF fibrils induce mitochondrial dysfunction via membrane disruption to cause apoptosis.
  • Image Slideshow

    Cloaking Nanoparticles with Protein Corona Shield.

    Targeted drug delivery using nanoparticles can minimize the side effects of conventional pharmaceutical agents and enhance their efficacy. So we present a targeting strategy for nanoparticles incorporated with a supramolecularly pre-coated recombinant fusion protein.
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Ryu Group at UNIST : Supramolecular Chemistry From Molecules To Materials

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