76) M. T. Jeena, K. Jeong, Y.i Cho, S. Jin, J. C. Kim, J. H. Lee, S. Lee, S.-W. Hwang, S. K. Kwak,* Sehoon Kim,* J.-H. Ryu,*  "Drug-Free Supramolecular Chemotherapy" submitted

75) H. Jang, J.-B. Chae, K. S. Cho, H. Choi, S. Jin, H.-Y. Lee, Y. Kim, H. Lee, J.-H. Ryu, N. Kim, C. Kim*, H. Chung*,   "Senolytic anti-aging therapy in AMD" under revision

74) B. Jana , D. Kim , H. Choi, M. Kim, K. Kim , S. P. Kim, S. Jin, M.-H. Park , K. H. Lee , C. Yoon, B.-S. Lee, M.-S. Kang, H.-J. Lim, E.-J. Park,* Y. Jeong,* J.-H. Ryu,* C. Kim,*  "Drug resistance-free cytotoxic nanodrug in composite for cancer therapy"  J. Mater. Chem. B, 2021, in press

73) T. H. Hong, M. T. Jeena, O.-H. Kim, K.-H. Kim, H. J. Choi, K. H. Lee, H.-E. Hong,  J.-H. Ryu, S.-J. Kim*   "Application of self‑assembly peptides targeting the mitochondria as a novel treatment for sorafenib‑resistant hepatocellular carcinoma cells Sci. Rep. 202111, 874


72) S. Kim, J. Kim, B.Jana, J.-H. Ryu,*  "Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emissionRSC Adv., 2020, 10, 43383

Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission

71) S. Jin, M. T. Jeena, B. Jana, M. Moon, H. Choi, E. Lee, J.-H. Ryu,*  "Spatiotemporal Self-Assembling Peptides Dictates Cancer-Selective ToxicityBiomacromolecules 2020, 21, 12, 4806–4813

Biomacromolecules cover

70) D. J. Kim, M. T. Jeena, O.-H. Kim, H.-E. Hong, H. Seo,  J.-H. Ryu, S.-J. Kim*   "Novel Therapeutic Application of Self-Assembly Peptides Targeting the Mitochondria in In Vitro and In Vivo Experimental Models of Gastric CancerInt. J. Mol. Sci.  202021, 6126

Novel Therapeutic Application of Self-Assembly Peptides Targeting the Mitochondria in In Vitro and In Vivo Experimental Models of Gastric Cancer

69) B. Jana, A. P. Thomas, S. Kim, I. S. Lee, H. Choi, S. Jin, S. A. Park, S. K. Min,* C. Kim,*  J.-H. Ryu*  "Self-Assembly of Mitochondria-Targeted Photosensitizer to Increase Photostability and Overcome Hypoxia in Photodynamic TherapyChem. Eur. J. 2020, 26, 10695-10701


68) M. T. Jeena, S. Lee, A. K. Barui, S. Jin, Y Cho, S.-W. Hwang, S. Kim,* J.-H. Ryu,*  "Intra-Mitochondrial Self-Assembly to Overcome the Intracellular Enzymatic Degradation of L-Peptides" Chem. Commun. 2020 56, 6265-6268


67) S. Hu, M. Ferraro, A. P. Thomas, J. Min Chung, N. G. Yoon, J.-H. Seol, S. Kim, H.-u. Kim, M. Y. An, H. Ok, H. S. Jung, J.-H. Ryu,* G. Colombo,*  B. H. Kang,*  "Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug " J. Med. Chem. 2020, 63, 2930–2940


66) M. T. Jeena, S. Kim, S. Jin, J.-H. Ryu,*  "Recent Progress of Mitochondria-targeted Drug and Drug-free Agents for Cancer Therapy"Cancers  2020, 12, 4 (invited review)


65) B. Jana, S. Kim, H. Choi, S. Jin, K. Kim, M. Kim, H. Lee, K. Lee, M.-H. Park, Y. Jeong,* J.-H. Ryu,* C. Kim* "Supramolecular protection-mediated one-pot synthesis of cationic gold nanoparticles" J. Ind. Eng. Chem. 2020, 81, 303-308


64) A. K. Barui, J. Y Oh, B. Jana, C. Kim,* J.-H. Ryu**"Cancer-targeted nanomedicine: overcoming the barrier of protein corona" Adv. Therapeutics 2020, 3, 1900124 (invited review)


63) J. Ryu, S. Kim, J. Kim, S, Park, S. Lee, S. Yoo, J. Kim, N.-S. Choi, J.-H. Ryu,* S. Park,*   "Room-temperature Cross-linkable Natural Polymer Binder for High-rate and Stable Silicon AnodesAdv. Funct. Mater. 2020, 30, 1908433



62) A. P. Thomas, A.-J. Lee, L. Palanikumar, B. Jana, K. Kim, S. Kim, H. Ok, J. Seol, D. Kim, B. H. Kang,* J.-H. Ryu* "Mitochondrial Heat Shock Protein-Guided Photodynamic TherapyChem. Commun., 2019, 55, 12631-12634


61) M.T. Jeena, K. Jeong, E. M. Go, Y. Cho, S. Lee, S. Jin, S.W. Hwang, J. H. Jang, C. S. Kang, W.-Y. Bang, E. Lee, S. K. Kwak,* S. Kim,* J.-H. Ryu**"Heterochiral Assembly of Amphiphilic Peptides inside the Mitochondria for Supramolecular Cancer Therapeutics" ACS Nano.201913, 11022-11033


60) Kibeom Kim, Sungmin Lee, Eunji Jin, L Palanikumar, Jeong Hyeon Lee, Jin Chul Kim, Jung Seung Nam, Batakrishna Jana, T,-H, Kwon*, S, K, Kwak*, Wonyoung Choe*, and J,-H, Ryu* "MOF X Biopolymer: Collaborative Combination of Metal-Organic Framework and Biopolymer for Advanced Anticancer Therapy" ACS Appl. Mater. Interfaces, 2019, 11, 27512-27520


59) Kibeom Kim, Huyeon Choi, Eun Seong Choi, Myoung-Hwan Park,* and J,-H, Ryu,*  " Hyaluronic Acid-Coated Nanomedicine for Targeted Cancer TherapyPharmaceutics 2019, 11, 301 ( June 30 2019 ) (invited review)


58) Y. Lu, L. Palanikumar, E. S. Choi, J. Huskens, J.-H. Ryu,* Y. Wang, W. Pang,* X. Duan* "Hypersound-Enhanced Intracellular Delivery of Drug-Loaded Mesoporous Silica Nanoparticles in a Non-Endosomal PathwayACS Appl. Mater. Interfaces 2019, 11, 19734-19742 (May. 15, 2019)


57) J. Hwang, M. Kang, M. I. Sari, T. H. Lee, K. Kim, Y. K. Choi, E. Lee, J.-H. Ryu, S. K. Baek, D. J. Ahn, P. C. W. Lee*, M. Kwak* "Phosphate-Functionalized Stabilized F127 Nanoparticles: Introduction of Discrete Surface Charges and Electrophoretic Determination of Aggregation NumberMacromol. Res. 2019, 27, 657-662 (Apr. 25, 2019)

56) J. Song, E. Hwang, Y. Lee, L. Palanikumar, S.-H. Choi, J.-H. Ryu, B.-S. Kim* "Tailorable Degradation of pH-Responsive All Polyether Micelles via Copolymerisation with Varying Acetal GroupsPolym. Chem. 2019, 10, 582-592 (Feb. 07, 2019)


55) J. Y. Oh, H. S. Kim, L. Palanikumar, E. M. Go, B. Jana, S. A. Park, H. Y. Kim, K. Kim, J. K. Seo, S. K. Kwak, C. Kim,* S. Kang,* J.-H. Ryu* "Cloaking Nanoparticles with Protein Corona Shield for Targeted Drug Delivery" Nat. Commun. 2018,  9, 4548 (Aug. 31, 2018)

Screen Shot 2018-10-31 at 5.42.44 PM

54) H. Choi, S. Kim, S. Lee, C.  Kim*, J.-H. Ryu* "Array-based Protein Sensing Using an Aggregation-induced Emission (AIE) Light-up Probe" ACS omega 2018,  3, 9276-9281 (Aug. 16, 2018)


53) L. Palanikumar, E. S. Choi, J. Y. Oh, S. A. Park, H. Choi, K. Kim, C. Kim, J.-H. Ryu* "Importance of Encapsulation Stability of Nanocarriers with High Drug Loading Capacity for Increasing in Vivo Therapeutic Efficacy" Biomacromolecules 201819 (7),  3030–3039. (Jul. 9, 2018)


52) L. Palanikumar, J. Kim, J. Y. Oh, H. Choi, M.-H. Park,*, C. Kim,* J.-H. Ryu* "Hyaluronic Acid-Modified Polymeric Gatekeepers on Biodegradable Mesoporous Silica Nanoparticles for Targeted Cancer Therapy" ACS Biomater. Sci. Eng. 2018, 4, 1716-1722. (May 14, 2018)

acs bse

51) H. Park, Y. Choi, M. T. Jeena, E. Ahn, Y. Cho, M.-G. Kang, C. G. Lee, T.-H. Kwon, H.-W. Rhee, J.-H. Ryu, B.-S. Kim* "Reduction-Triggered Self-Cross-Linked Hyperbranched Polyglycerol Nanogels for Intracellular Delivery of Drugs and ProteinsMacromol. Biosci. 2018, 1700356. (Apr. 17, 2018)

50) S. Kim, L. Palanikumar, H. Choi, M. T. Jeena, C. Kim*, J.-H. Ryu* "Intra-Mitochondrial Biomineralization for Inducing Apoptosis of Cancer Cells" Chem. Sci. 2018, 9, 2474-2479. (Mar. 7, 2018)


49) Yang, S.; Palanikumar, L.: Jeong, S.; Kim, K.; Lee, J.; Kim, C.;* Ryu, J.-H.;* Park, M.-H.* "Synergistic Effect of Photothermal Therapy and Photochemotherapy using Camptothecin-conjugated Gold Nanorods" Part. Part. Syst. Char. 2018, 35, 1700307. (Feb. 21, 2018)



48) Song, J.; Palanikumar, L.; Choi, Y.; Kim, I.; Heo, T.-y.; Ahn, E.; Choi,  S.-H.; Lee, E.; Shibasaki, Y.; Ryu, J.-H.; Kim, B.-S.*  "The Power of the Ring: pH-Responsive Hydrophobic Epoxide Monomer for Superior Micelle Stability" Polym. Chem. 2017, 8, 7119 (December 14, 2017)

47) Thomas, A. P.; Palanikumar, L.; Jeena, M.T.; Kim, K.; Ryu, J.-H.* "Cancer Mitochondria-Targeted Photodynamic Therapy with Supramolecular Assembly of HA and Near IR Cyanine Dye" Chem. Sci. 20178, 8351 (December 01, 2017)


46) Jeena, M. T.; Palanikumar, L.; Go, E. M.; Kim, I.; Kang, M. G.; Lee, S.; Park, S.; Choi, H.; Kim, C.; Jin, S.-M.; Bae, S. C.; Rhee, H.-W; Lee, E.; Kwak, S. K.; Ryu, J.-H.* "Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction" Nat. Commun. 2017, 8, 26 (June, 21, 2017) (News: KBS, Arirang TV)

제목 없음

45) Palanikumar, L.; Jeena, M. T.; Kim, K.; Oh, J. Y.; Kim, C.; Park, M.-H.; Ryu, J.-H.* "Spatiotemporally and Sequentially-Controlled Drug Release from Polymer Gatekeeper-Hollow silica Nanoparticles" Sci. Rep. , 2017, 7, 46540 (April, 24, 2017)


44) Cho, A; La, Y; Jeoung, S; Moon, H.R; Ryu, J.-H; Shin, T; Kim, K.T.* "Mix-and-Match Assembly of Block copolymer Blends in Solution" Macromolecules, 2017(April, 4, 2017)


43) Kim, K.; Choi, H.; Choi, E.; Ryu, J.-H.*  “Encapsulation stability of the polymeric assembly (고분자 조립체의 Encapsulation 안정성) "고분자 과학과 기술 제27권 제2호, 2016.4, 142-147. Polymer Society of Korea (mini-review, written in Korean)

42) Kim, K.; Jo, M.C.; Jeong, S.;  Palanikumar, L.; Rotello, V. M.; Ryu, J.-H.*; Park, M.-H.*  "Externally controlled drug release using a gold nanorod contained composite membrane" Nanoscale , 2016, 8, 11949-11955. (May, 17, 2016)

Externally controlled drug release using a gold nanorod contained composite membrane

41) Choi, H.; Jeena, M.T.; Palanikumar, L.; Jeong, Y.; Park, S.; Lee, E.*; Ryu, J.-H.* "HA-incorporated nanostructure of peptide-drug amphiphile for targeted anticancer drug delivery" Chem. Commun. 201652, 5637-5640. (Mar, 22. 2016)

The HA-incorporated nanostructure of a peptide–drug amphiphile for targeted anticancer drug delivery

40) Jeena, M. T.; Bok, T; Kim, S. H.; Park, S.; Kim, J.-U.; Park, S.*; Ryu, J.-H.*  “Siloxane incorporated copolymer as an in situ cross-linkable binder for high performance silicon anode in Li-ion battery" Nanoscale 2016, 8,9245-9253. (Mar. 30, 2016)

Siloxane incorporated copolymer as an in situ cross-linkable binder for high performance silicon anode in Li-ion battery


39) Palanikumar, L.; Kim, H.: Oh, J. Y.; Thomas, A. P.; Choi, E. S.; Jeena, M. T.; Joo, S. H.; Ryu, J.-H.*  “Noncovalent Surface Locking of Mesoporous Silica Nanoparticles for Exceptionally High Hydrophobic Drug Loading and Enhanced Colloidal Stability" Biomacromolecules 201516, 2701-2714. (Sep. 14, 2015)


38) Yang, S. H.*; Choi, J.; Palanikumar, L.; Choi, E. S.; Lee, J.; Kim, J.; Choi, I. S.*; Ryu, J.-H.*  “ Cytocompatible In Situ Cross-Linking of Degradable LbL Films Based on Thiol-Exchange Reaction  Chem. Sci. 2015, 6, 4698-4703.(Aug. 01, 2015)


37) Lee, C.*; Park, H.-K.; Jeong, H; Lim, J.;Lee, A.-J.; Cheon, K. Y.; Kim, C.-S.; Thomas, A. P.; Bae, B.; Kim, N. D.; Kim, S. H.; Suh, P.-G.; Ryu, J.-H.*; Kang, B. H.*  “ Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J. Am. Chem. Soc. 2015, 137, 4358-4367. (Apr. 8, 2015)


36) Palanikumar, L.; Choi, E. S.; Cheon, J. Y.; Joo, S. H.*; Ryu, J.-H.*  “Noncovalent Polymer-Gatekeeper in Mesoporous Silica Nanoparticles as a Targeted Drug Delivery Platform" Adv. Funct. Mater. 2015, 25, 957-965.(Feb. 11, 2015)



35) Jeena, M. T.; Lee, J.-I; Kim, S. H.; Kim, C.; Kim, J.-Y.; Park, S.*; Ryu, J.-H.*  “Multifunctional Molecular Design as an Efficient Polymeric Binder for Silicon Anodes in Lithium-Ion Batteries ACS Appl. Mater.  Interfaces 2014 6, 18001–18007. (Oct. 22, 2014)



34) Kim, K.; Bae, B.; Kang, Y. J.; Nam, J.-M.; Kang, S.; Ryu, J.-H.*  “ Natural Polypeptide-Based Supramolecular Nanogels for Stable Noncovalent Encapsulation Biomacromolecules 2013, 14, 3515-3522.  (Oct. 14, 2013)


33) Li, L.; Ryu, J.-H.; Thayumanavan, S.  “ Effect of Hofmeister Ions on the Size and Encapsulation Stability of Polymer Nanogels Langmuir 2013, 29, 50-55. (Jan. 8, 2013)


Prior to joining UNIST

32) Kim, H.-J. +; Liu, F. +; Ryu, J.-H. +; Ungar, G.; Lee, J.-K.; Zin, W.-C.; Lee, M. “Self-Organization of Bent Rod Molecules into Hexagonally-Ordered Vesicular Columns J. Am. Chem. Soc. 2012, 134, 13871-13880. (+These authors contributed equally to this work)

31) Choi, I.; Park, I.-S.; Ryu, J.-H.; Lee, M. “Control of Peptide Assembly Through Directional InteractionsChem. Commun. 2012, 48, 8481-8483. (Selected to inside Cover). 

30) Gonzalez, D.+; Ryu, J.-H.+; Chacko, R. T.; J. Zhuang; Thayumanavan, S. “Concurrent Binding and Delivery of Proteins and Lipophilic Small Molecules Using Polymeric NanogelsJ. Am. Chem. Soc. 2012, 134, 6964-6967. (+ These authors contributed equally to this work)

29) Ryu, J.-H.; Bickerton, S.; J. Zhuang; Thayumanavan, S. “Ligand-Decorated Nanogels: Fast One-Pot Synthesis and Cellular TargetingBiomaromolecules 2012, 13, 1515-1522

28) Ryu, J.-H.; Chacko, R. T.;  Jiwpanich, S.; Bickerton, S.; Babu, R. P.; Thayumanavan, S.  “Self-crosslinked polymer nanogels: a novel platform for intracellular delivery vehiclesJ. Am. Chem. Soc. 2010, 132, 17227-17235.

27) Jiwpanich, S.; Ryu, J.-H.; Bickerton, S.; Thayumanavan, S. “Noncovalent Encapsulation Stabilities in Supramolecular NanoassembliesJ. Am. Chem. Soc. 2010, 132, 10683-10685

26) Ryu, J.-H.; Jiwpanich, S.; Chacko, R.; Bickerton, S.; Thayumanavan, S. “Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation CapabilitiesJ. Am. Chem. Soc. 2010, 132, 8246-8247.

25) Ryu, J-H.; Roy, R.; Ventura, J. Thayumanavan, S. Redox-Sensitive Disassembly of Amphiphilic Copolymer Based MicellesLangmuir 2010, 26, 7086-7092. 

24) Ryu, J.-H.; Park, S.; Kim, B.; Klaikherd, A.; Russell, T. P.; Thayumanavan, S. “Highly Ordered Gold Nanotubes Using Thiols at a Cleavable Block Copolymer interfaceJ. Am. Chem. Soc. 2009, 131, 9870-9871.

22) Ryu, J.-H.; Lee, M. “Liquid Crystalline Assembly of Rod-Coil MoleculesStructure and Bonding 2008, 128, 63-98. (Review Article)

21) Ryu, J.-H.; Hong, D.-J.; Lee, M. “Aqueous Self-Assembly of Aromatic Rod Building BlocksChem. Commun.2008, 1043-1054. (Feature Article)

20) Ryu, J.-H.; Tang, L.; Lee, E.; Kim, H.-J.; Lee, M. “Supramolecular Helical Columns from Self-Assembly of Chiral Rods Chem. Eur. J. 2008, 14, 871-881

19) Huang, Z.; Ryu, J.-H.; Lee, E.; Lee, M. Tunable Columnar Organization by Twisted Stacking of End-Capped Aromatic Rods Chem. Mater. 2007, 19, 6569-6574.

18) Lim, Y.-b.; Park, S.; Lee, E.; Ryu, J.-H.; Yoon, Y.-R.; Kim, T.-H.; Lee, M. Tunable Bacterial Agglutination and Motility Inhibition by Self-Assembled Glyco-Nanoribbons Chem. Asian J. 2007, 2, 1363-1369. (Cover Picture)

17) Lee, E.; Ryu, J.-H.; Park, M.-H.; Lee, M.; Han, K.-H.; Chung, Y.-W.; Cho, B.-K. “Observation of an unprecedented body centered cubic micellar mesophase from rod–coil moleculesChem. Commun. 2007, 2920-2922.

16) Ryu, J.-H.; Lee, E.; Lim, Y.-b.; Lee, M. Carbohydrate-Coated Supramolecular Structures: Transformation of Nanofibers into Spherical Micelles Triggered by Guest Encapsulation J. Am. Chem. Soc. 2007, 129, 4808-4814.

15) Lim, Y.-b.; Park, S.; Lee, E.; Jeong, H.; Ryu, J.-H.; Lee, M.S.; Lee, M. “Glycoconjugate Nanoribbons from Self-Assembly of Carbohydrate-Peptide Block Molecules for Controllable Bacterial Cell Cluster FormationBiomaromolecules 2007, 8, 1404-1408.

14) Park, M.-H.; Ryu, J.-H.; Han, K.-H.; Chung, Y.-W.; Cho, B.-K.; Lee, M. Chain Architecture Dependent 3-Dimensional Supramolecular Assembly of Rod-Coil Molecules with Conjugated Hexa-p-phenylene RodMacromol. Rapid. Commun. 2006, 27, 1684-1688.

13) Ryu, J.-H.; Cho, B.-K.; Lee, M. Supramolecular Assembly of Rigid-Flexible Block Molecules into Organized Nanostructures Bull. Kor. Chem. Soc. 2006, 27, 1270-1282. (Review Article)

12) Ryu, J.-H.; Kim, H.-J.; Huang, Z.; Lee, E.; Lee, M. Self-Assembling Molecular Dumbbell: From Nanohelices to Nanocapsules Triggered by Guest Intercalation  Angew. Chem. Int. Ed. 2006, 45, 5304-5307.

11) Jin, Y.J.; Bae, J.; Ryu, J.-H.; Lee, M. Ordered Nanostructures from Self-Assembly of Reactive Coil-Rod-Coil Molecule Angew. Chem. lnt. Ed. 2006, 45, 650-653.

10) Ryu, J.-H.; Lee, M. Transformation of Isotropic Fluid to Nematic Gel Triggered by Dynamic Bridging of Supramolecular Nanocylinders.J. Am. Chem. Soc. 2005, 127, 14170-14171.

9) Ryu, J.-H.; Jang, C.-J.; Yoo Y.-S.; Lim, S.-G.; Lee, M. “Supramolecular Reactor in Aqueous Environment: Aromatic Cross Suzuki Coupling Reaction at Room TemperatureJ. Org. Chem. 2005, 70, 8956-8962.

8) Kim, B.-S.; Yang, W.-Y.; Ryu, J.-H.; Yoo, Y.-S.; Lee, M. Carbohydrate-Coated Nanocapsules from Amphiphilic Rod-Coil Molecule: Binding to Bacterial Type 1 PiliChem Commun. 2005, 2035-2037.

7) Ryu, J.-H.; Bae, J.; Lee, M. “Helical Organization of m-Linked Rigid Polymers with Pendant Flexible DendronsMacromolecules 2005, 38, 2050-2052.

6) Ryu, J.-H.; Oh, N.-K.; Lee, M. Tubular Assembly of Amphiphilic Rigid Macrocycle with Flexible DendronsChem. Comm. 2005, 1770-1772.

5) Jang, C.-J.; Ryu, J.-H.; Lee, J.-D.; Shon, D.; Lee, M. “Synthesis and Supramolecular Nanostructure of Amphiphilic Rigid Aromatic-Flexible Dendritic Block MoleculesChem. Mater. 2004, 16, 4226-4231.

4) Lee, M; Jang, C.-J.; Ryu, J.-H.Supramolecular Reactor from Self-Assembly of Rod-Coil Molecule in Aqueous EnvironmentJ. Am. Chem. Soc. 2004, 126, 8082-8083.

3) Oh, N.-K.; Zin, W.-C.; Im, J.-H.; Ryu, J.-H.; Lee, M. Organization of Branched Rod-Coil Molecule into a 3-D Tetragonally Perforated Lamellar StructureChem. Commun. 2004, 1092-1093.

2) Ryu, J.-H.; Oh, N.-K.; Zin, W.-C.; Lee, M. Self-Assembly of Rod-Coil Molecules into Molecular Length-Dependent OrganizationJ. Am. Chem. Soc. 2004, 126, 3551-3558.

1) Cho, B.-K.; Ryu, J.-H.; Zin, W.-C.; Lee, M. “Synthesis of Liquid Crystalline Rod-Coil Dimers based on Poly(propylene oxide) Coil” Polym. Bull. 2000, 44, 393-400.