Research

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Self-assembled structures in Nature play essential roles in living systems, such as, in protein folding and the formation of biological membranes. The formation of most biological nanostructures is driven by self-assembly processes. For example, the self-assembly of phospholipids forms cell membranes, DNA forms a double helix through specific hydrogen bonding of individual strands, and proteins form by the folding of polypeptide chains to make defined tertiary and quaternary structures. Nature has inspired us to make biomimetic self-assembled structures. Furthermore, the assembly and transformation of biomacromolecules in response to a signal (or a stimulus) is an important component to most of Nature’s functions and signaling mechanisms. Given the versatile nature of such stimuli-responsive assembly and disassembly processes, it is desirable to understand and develop ways by which artificial, responsive supramolecular assemblies could be achieved. Development of artificial assemblies with nature’s specificity and versatility stands as an enormous intellectual challenge and custom-designed stimuli-sensitive supramolecular assemblies have potential in a variety of applications.    Thus, one of the important areas of research that evolved from the process of self-assembly is concerned with the construction of novel supramolecular, nanoscopic architectures that are convertible to another structure by external stimuli. Consequently, the development of controllable nano-architectures through self-assembly processes of the designed molecules will have a significant impact in the fields of nano-science and bio-science.        

 Nanomedicine for Cancer Therapy

  Facile Preparation of Biogradable Nanogel for Intracellular Drug Deliver    

  Versatile Ligand-Functionalization of Polymeric Nanogel for Targeting Delivery      

  Concurrent Intracellular Delivery of Small Drug Molecules and Cellular Impermeable Protein    

  Mitochondria Targeting Drug     

   Mitochondrial TRAP1 inhibitor

  Bioactive Supramolecular Assembly  

   Carbohydrate-Coated Nanofibers for Immobilization of Bacterial Cells  

   Self-Assembly of Coil-Rod-Coil Molecules in Aqueous Solution  

  Multifunctional Polymeric Binder for Lithium Ion Batteries    

   Multifunctional Molecular Design as an Efficient Polymeric Binder for Silicon Anodes in Lithium-Ion Batteries